The Indians in question were either non-sedentary or semi-sedentary. That means that they did not stay in one location, therefore, they did not have land. They are lucky that Henry Knox decided to push to recognize Indian land title at all. The Indians themselves initially wanted none of it, but people, like Thomas Jefferson, believe that the Indians were capable of civilization and convinced Indians to accept land title. The original Indian policy attempted to assimilate Indians into American society, and buy their land from them, as they would no longer need such massive areas to live in. These efforts to assimilate them were actually successful in many instances, most notably the Cherokees, Creeks, and Seminoles. Some of the Indians were, however, not keen on assimilation, and they fought against it. Look at the story of Techumseh, and the Red Stick Rebellion. The Indians were not innocent. Neither were the whites, but in most cases, they had some kind of provokation and didn't just kill Indians for the hell of it.